Model step 1 demonstrated the age and sex-adjusted efficiency

Basic, we omitted instances clinically determined to have hypertension in the standard since these players had been more likely to transform their losing weight habits shortly after seeing exposure

Immediately after draining the bladders, the participants seated privately for over five full minutes. The hypertension try counted using a great calibrated mercury sphygmomanometer from the an experienced fitness nurse after the a standard process. The players placed its proper sleeve for the good cuff airbag, measured at the very least 1 min between recordings. I laid out blood pressure people that a mean away from SBP ? 140 mmHg, a hateful from DBP ? 90 mmHg, or bringing antihypertensive treatment with respect to the guidance to have stopping and you will dealing with blood circulation pressure in Asia (2010) 23 . Diabetic issues and you will myocardial infarction was indeed discussed considering care about-statement from analysis by the a health care provider in public places hospitals over the condition peak. The participants ought to provide the brand new certification from diabetic issues or myocardial infarction. Detectives have to ensure this new person’s diagnosis away from research and you will query all the questions ‘Provides a health care provider actually given the prognosis from jak usunД…Д‡ konto plenty of fish all forms of diabetes?

Has actually a doctor ever before offered you the analysis of myocardial infarction? Therapy use are laid out according to the participants’ self-statement, where investigators must ask the players next questions: ‘Could you be getting anti-hypertension drugs? Do you make use of the dental treatments, shot from insulin, Chinese traditional medication, or do-it-yourself solutions to treat diabetes? With regards to the guidelines to your prevention and remedy for blood lipids for the Chinese grownups (2006), members whom fulfilled at least one of your own following requirements: (1) TC ? six. We as well as considered most other weight-loss covariates, particularly complete fat reduction opportunity, opportunity, grain, red meat, good fresh fruit, make, soaked oily acidic, polyunsaturated fatty acidic, cereal soluble fiber, Na, K, and you may cholesterol intake, because the surrogates to handle possible weight loss confounding.

Statistical analysis

The collective average intake regarding calcium, magnesium, and you may phosphorus is calculated to minimize within-individual adaptation which means obtain a knowledgeable guess of your own much time-identity consumption. Person-several years of go after-up per fellow member was determined given that interval within go out of doing of the standard survey as well as the prevent from follow-right up (the fresh new date of history see or the head to away from stroke diagnosis), almost any emerged basic. The latest frequency speed is actually determined from the dividing exactly how many circumstances because of the people-years of realize-up. The latest multivariate Cox proportional dangers models were used so you can imagine the new possibilities percentages (HR) and 95% depend on menstruation (95% CI) of making coronary arrest considering fat loss calcium, magnesium, and phosphorus intake utilizing the reasonable quartile because the reference class. Regarding the Cox proportional threats activities, the brand new p getting trend is done by acting the fresh average out-of the groups defined by the for every single quartile as a continuing variable.

We first performed statistical interaction tests between dietary intakes of calcium, magnesium, phosphorus, and other baseline characteristics (Table 1). We used the Kolmogorov-Sminov test to test the normality of all variables. We outlined the baseline characteristics of the participants. We used the t-test for the continuous variables with normal distribution to test for differences and trends between groups. The non-parametric test is applied to the continuous variables with non-normal distribution, and the chi-square test is used for the classified variables. Then, we categorize the three-day average intakes of calcium, magnesium, phosphorus into four levels. We constructed three sequential models to estimate the effect of calcium, magnesium, phosphorus intakes on stroke. Model 2 further added baseline sociodemographic and lifestyle factors such as urbanization index, education, household income, smoking status, alcohol intake, physical activity, BMI, hypertension, diabetes, myocardial infarction, and medication use into the multivariable analysis. Model 3 additionally adjusted for dietary factors including energy (kcal/d), whole grain (g/d), red meat (g/d), fruits (g/d), vegetables (g/d), saturated fatty acid (g/d), polyunsaturated fatty acid (g/d), cereal fiber (g/d), Na (mg/d), K (mg/d) and cholesterol (g/d) 24,25,26 . To further analyze which factors would affect the relationship between the exposure and outcome, we conducted stratified analyses by age at baseline (< 60 and ? 60 years), sex (man and woman), smoking (never and ever), drinking (never and ever), BMI (< 24, 24–28 and > 28 kg/m 2 ), hypertension, diabetes, and Myocardial infarction. The likelihood ratio test was used to assess the interactions of cross-product terms. The proportional hazards assumption for dietary calcium, magnesium, phosphorus Intakes, and other covariates was checked by Schoenfeld’s residuals, and no violation was found (P > 0.05). Besides, we performed sensitivity analyses to verify the robustness of the primary results. Second, we repeated the analysis using the non-adjusted person-time from the date of the first visit to the time of the most recent visit of stroke diagnosis or to the end of follow-up, whichever came first. Third, we included dyslipidemia as a sensitivity analysis, which confirmed the robustness of our findings to some degree. Tests for trends across dietary intake categories were conducted by modeling the median value in each quartile as a continuous variable in each model. All statistical analyses were performed with STATA version 14.0. All P-values were two-sided, and P < 0.05 was considered to statistical significance.